NIP Country Case Series | Lessons Learned from the Public-Private Partnership for HPV Vaccination in Rwanda

Following the end of the war in 1994, the Rwandan government prioritized healthcare as a key focus for national reconstruction. As a low-income country in East Africa, Rwanda has long faced a significant burden of cervical cancer, which ranks as a leading cause of female cancer and death. Before 2011, the age-standardized incidence rate of cervical cancer was 34.5 cases per 100,000 women, with an age-standardized mortality rate of 25.4%[1]. Due to weak health infrastructure, most patients were diagnosed at an advanced stage of cervical cancer. To address this public health challenge, the Rwandan government designated cervical cancer a health priority in 2008 and formally launched the National HPV Vaccination Program in 2011, becoming the first low- and middle-income country in Africa to implement such an initiative.

Public-Private Partnerships Facilitates National Cervical Cancer Prevention Strategy

In April 2009, Rwanda’s First Lady met with senior executives from Merck to initiate advocacy for the HPV vaccine on behalf of women in Rwanda. An internal technical discussion then occurred between Merck and the Ministry of Health, followed by conversations with development partners in Rwanda’s health sector. Under the Ministry’s leadership, Merck also contributed to developing the National Strategic Plan for the Prevention, Control, and Management of Cervical Lesions and Cancer. This plan included a vaccination program (3-dose schedule) for school-aged girls and routine cervical screening for women aged 35 to 45[1].

A memorandum of understanding signed in December 2010 guaranteed Rwanda three years of vaccinations at no cost and concessional prices for future doses[2]. As the Rwandan government lacked sufficient financial resources to independently fund the program, agreements were established with Qiagen (a provider of HPV testing products) and the Global Alliance for Vaccines and Immunization (Gavi) to ensure the sustainability and continuity of Rwanda’s cervical cancer elimination efforts. Following the conclusion of the three-year collaboration with Merck, Gavi agreed to cover the cost of the vaccines supplied by Merck[1], supporting Rwanda’s HPV program through a co-financing model. Under this arrangement, Rwanda pays $0.20 per vaccine dose, with Gavi covering the remainder[1].

Flowchart of Kingdon’s MSF framework used to clarify the HPV vaccination policymaking process in Rwanda[1].

The Health Sector Drives Vaccination Implementation

Driven by the principles of equity, value and quality, Rwanda’s health sector has demonstrated significant progress in recent years. The Rwandan government enshrined a commitment to prioritize health as a human right in its constitution (Article 41), stating that “All citizens have rights and duties relating to health”. The State is responsible for mobilizing activities aimed at promoting good health and assists in implementing them [1, 2].

On 26 and 27 April 2011, 93,888 Rwandan girls in primary school grade six received their first dose of the HPV vaccine free of charge. Data indicates that the coverage rate for the full three-dose HPV vaccination series reached 93.23%[2]. Three strategic decisions were critical to Rwanda’s successful HPV vaccine rollout[2]:

First, in September 2010, the Ministry of Health expanded its Vaccination Technical Working Group to include representatives from the Ministry of Education, the Ministry of Gender and Family Promotion, the National Center for Research and Control of AIDS, Tuberculosis, Malaria and Other Epidemics, and healthcare workers involved in cancer care. This technical working group was tasked with defining cold chain requirements, determining the number of school-going and out-of-school girls, designing tools for nurse and community health worker capacity training, and supervising the procurement and distribution logistics, implementation budgets, education and advocacy, data collection, and social mobilization. In the months preceding vaccination implementation, the government also spearheaded a nationwide awareness campaign. The First Lady delivered a mobilization speech, and healthcare professionals, local government officials, clergy, and others educated parents and children about the new vaccine.

Second, since 98% of Rwandan girls attend primary school, the Ministry of Health collaborated with the Ministry of Education to design a school-based implementation strategy for delivering the standard three-dose HPV vaccine schedule to achieve maximum coverage. To ensure eligible girls did not miss vaccination opportunities, Rwanda mobilized 45,000 community health workers to actively track girls enrolled in sixth grade who were absent on vaccination days, as well as a small number of girls aged 12 who were not enrolled in school. After confirmation by community health workers, both groups received vaccinations at local health centers.

Third, the technical working group decided on a multi-phased vaccination strategy spanning three years. Every year beginning in 2011, girls enrolled in primary grade six will receive the full three-dose course of HPV vaccine. During the programme’s second and third years, a “catch-up” phase targeting girls in the third year of secondary school will ensure complete coverage of all pre-adolescent and adolescent girls. In 2014 and beyond, only primary grade six vaccinations will be necessary.

Challenges and Resistance

During the initial phase of vaccine rollout, one of the greatest challenges for implementers was communicating eligibility criteria for HPV vaccination to residents nationwide. Some parents requested vaccination for all their children, and some female teachers also sought access. Through radio broadcasts and in-person outreach, Ministry of Health representatives acknowledged the potential benefits of vaccinating all women at high risk for cervical cancer but clarified that the national program targeted only girls before their first sexual encounter.

Although Rwanda’s policy environment remained stable throughout the HPV vaccine decision-making process, stakeholder resistance persisted. Academics wrote to The Lancet expressing “serious doubts about whether this arrangement [Rwanda’s partnership with Merck] serves the best interests of the people.” Rwanda’s Minister of Health and colleagues responded to these arguments in a letter to The Lancet editors, highlighting the stable public discourse and policy environment supporting HPV vaccine implementation[1].

Additionally, concerns about the high cost of the new vaccine led some to argue that prioritizing cervical cancer prevention might divert scarce resources from other more “cost-effective” childhood health interventions. However, Rwanda government and Merck addressed challenges in health budget allocation and difficult decision-making by signing an agreement guaranteeing free HPV vaccines for the program’s first three years.

Program Outcomes and Implications

Through innovative partnerships, Rwanda narrowed the two-decade gap in vaccination coverage between high- and low-income countries to just five years. Between 2011 and 2018, 1,156,863 girls received their first HPV vaccine dose, reaching 98% of the eligible target population; population coverage among girls born between 2001 and 2006 (aged 12) increased from 80% to 90%[3]. Rwanda’s HPV vaccine rollout success was not accidental; it stemmed from robust coordination, national ownership, strategic planning, comprehensive monitoring (particularly training school teachers to report side effects and adverse reactions), and strong administrative capacity. Key lessons for other low- and middle-income countries include:

First, comprehensive planning, coordination, and political commitment. Rwanda leveraged limited existing resources to effectively implement the HPV vaccination program, including dedicated community health workers, diverse communication channels for vaccine outreach, advocacy from women’s rights groups and NGOs, and support from the First Lady of Rwanda. Research indicates that high-level government backing and strong political will were also critical factors in achieving 95% coverage within three years[4].

Second, effective internal and external partnerships drive success. The driving force behind public-private partnerships lies in leveraging diverse efforts to create shared value. Donating vaccines to Rwanda and other low-income countries and communities aligns with Merck’s interests, as this initiative not only fulfills corporate social responsibility but also serves as a marketing strategy. It provides a social operating license and channels for selling medicines to low-income countries and communities at reasonable costs and terms[1]. Following the conclusion of the three-year donation period, Rwanda engaged Gavi to cover vaccine-related procurement costs as a continuity package for program advancement. However, the program’s success also demonstrates that vaccine manufacturers’ involvement in vaccine policy decision-making processes influences policy outcomes. Furthermore, senior ministry of Health officials in Rwanda acknowledged that an emphasis on health systems strengthening by the government, the Gavi, the President’s Emergency Plan for AIDS Relief and the Global Fund to Fight AIDS, Tuberculosis and Malaria was key to the success of HPV vaccine rollout in the country[2].

Content Editors: Ziyi Zhu

Page Editor: Rurong Li

References

[1] Asempah E., Wiktorowicz M.E. Understanding hpv vaccination policymaking in Rwanda: A case of health prioritization and public-private-partnership in a low-resource setting. Int J Environ Res Public Health. 2023, 20(21).

[2] Binagwaho A., Wagner C.M., Gatera M., et al. Achieving high coverage in rwanda’s national human papillomavirus vaccination programme. Bull World Health Organ. 2012, 90(8): 623-628.

[3] Sayinzoga F., Umulisa M.C., Sibomana H., et al. Human papillomavirus vaccine coverage in rwanda: A population-level analysis by birth cohort. Vaccine. 2020, 38(24): 4001-4005.

[4] Ezezika, O., Purwaha, M., Patel, H. et al. The Human Papillomavirus Vaccine Project in Rwanda: Lessons for Vaccine Implementation Effectiveness. Glob Implement Res Appl 2, 394–403 (2022). https://doi.org/10.1007/s43477-022-00068-x

Others

代表性地区的基本情况、接种政策及效果、宣传推动情况

(1) 成都市

 

基本情况

成都市2022年度GDP为20817.5亿元,排名全国城市第七。成都市出台了《健康城市建设推动健康中国行动创新模式成都市宫颈癌综合防控试点工作方案》等一系列相关政策推动适龄女孩HPV疫苗接种工作。

接种政策及效果

目标人群为13-14岁在校且无HPV疫苗接种史女生。免疫程序为国产二价0-6二剂次、进口二价0-1-6三剂次、进口四价0-2-6三剂次。资助政策为国产二价疫苗(沃泽惠)免费,其它疫苗补贴600元/人,并自付20元/剂接种费。疫苗接种按照属地化管理原则,由学校所在地预防接种单位负责。截至2022年1月,目标人群首针接种率达90.04%[14]。

宣传推动

成都市开展多形式、多载体的健康教育宣传。形式包括讲座、知晓日、义诊咨询、专题课程、专题活动等,载体包括宣传册、宣传栏、展板、电视、微信、视频号、抖音平台等,覆盖相关医疗机构300余、社区300余个、和公众场所90余个。面向适龄女孩及监护人、适龄女性及全体市民开展广泛宣教,宣传材料发放至近9万名群众,讲座活动覆盖近2万名群众。宣教内容包括HPV疫苗接种、两癌防控、其它女性常见疾病防控等。

(2) 济南市

 

基本情况

济南市2022年度GDP为12027.5亿元,位列全国城市排名20。2021年,济南市出台《健康城市建设推动健康中国行动创新模式试点一济南市宫颈癌综合防治工作方案(2021—2025年)》等一系列相关政策推动适龄女孩HPV疫苗接种工作。

接种政策及效果

目标人群为≤14周岁且无HPV疫苗接种史的在校七年级女生。免疫程序为国产二价0-6二剂次。资助政策免费接种。疫苗接种按照属地化管理原则,安排分班级分时段前往学校所在地的预防接种单位进行接种。截至2022年11月,目标人群首针接种率达
94.4%[15].

宣传推动

济南市开展多形式、多载体的健康教育宣传。形式包括采访、线上线下专题活动,载体包括网络媒体、纸媒、科普展板、宣传手册、子宫颈癌与HPV疫苗知识读本、济南HPV疫苗接种手册,宣教人群广泛涵盖全体市民,宣教内容包括HPV疫苗接种、两癌防控等知识。

(3) 鄂尔多斯市

 

基本情况

鄂尔多斯市2022年度GDP为5613.44亿元,全国地级市第45位。2021年,鄂尔多斯市出台了《健康城市建设推动健康鄂尔多斯行动创新模式工作方案》等一系列相关政策推动适龄女孩HPV疫苗接种工作。

接种政策及效果

2020年8月,鄂尔多斯市在准格尔旗率先开展HPV疫苗免费接种项目。目标人群为全市当年13-18岁在校且无HPV疫苗接种史女生。免疫程序为进口二价0-1-6三剂次,

2023年起调整为13-14岁女孩0-6二剂次。资助政策为疫苗免费,自付20元/剂接种费。组织方式为疫苗接种服务中心根据任务安排联系学校,有规划的通知适龄女孩前来完成HPV疫苗接种。截至2022年11月,目标人群首针接种率接近70%[16]。

2022年8月,启动准格尔旗和达拉特旗高三女生接种四价和九价HPV疫苗的试点工作,利用暑假时间展开接种,力争在2023年年底达成90%的接种目标[17]。自鄂尔多斯之后,由政府主导的HPV疫苗惠民行动在多地等涌现。值得注意的是,近年来多主体参与到HPV疫苗支持项目,如慈善总会、医院、妇联等为主体单位牵头组织开展了一些公益活动。

宣传推动

鄂尔多斯市开展多形式、多载体的健康教育宣传。形式包括讲座、知晓日、义诊咨询、专题课程、专题活动等,载体包括宣传册、宣传栏、展板、电视、微信、视频号、抖音平台等,宣教人群广泛涵盖在校女孩及监护人,适龄女性及全体市民。宣教内容包括HPV疫苗接种、两癌防控、其它女性常见疾病防控等。

(4) 西安市

 

基本情况

西安市2022年度GDP为11486.51亿元,排名全国第22位。2021年,西安市出台了《西安市健康城市建设推动健康中国行动创新模式试点宫颈癌综合防治工作方案》等一系列相关政策推动适龄女孩HPV疫苗接种工作。

接种政策及效果

目标人群为全市年龄满13周岁(初中)在校女生。免疫程序为国产二价0-6二剂次,进口二价0-1-6三剂次,进口四价和进口九价0-2-6三剂次。接种政策为自愿自费。各区(县)合理设立HPV疫苗专项疫苗接种门诊承担接种任务,并及时将接种信息统一录入儿童免疫规划信息平台。

宣传推动

西安市出台了《西安市宫颈癌综合防治宣传方案》(市健办发〔2022〕12号)。通过媒体宣传、社区活动、义诊等形式,宣传册、宣传栏、展板、电视、微信公众号、报纸等载体普及宫颈癌防治相关知识。

(5) 西藏自治区

 

基本情况

西藏自治区2022年度GDP为2132.64亿元,经济总量整体规模相对其他省份较小,人均GDP处于全国中等偏下水平。2022年出台《西藏自治区妇女“两癌”综合防治工作实施方案》等系列政策推动适龄女孩HPV疫苗接种。

接种政策及效果

目标人群为13-14岁在校女生。免疫程序为国产二价0-6二剂次。资助政策为免费。由学校组织,接种者在商定接种时间携带个人身份证明材料与法定监护人一同前往定点接种单位接种。

宣传推动

充分利用网络、电视、广播、报刊等媒介,以群众喜闻乐见的宣传方式,对适龄在校女生HPV疫苗接种工作的意义及内容进行广泛宣传。

近年来各地HPV疫苗惠民项目信息

“疾病负担”指标解读

疾病负担(burden of disease, BOD)是指疾病造成的失能(伤残)、生活质量下降和过早死亡对健康和社会造成的总损失,包括疾病的流行病学负担和经济负担两个方面。

 

在疾病的流行病学方面,衡量疾病负担的常用指标包括传统指标和综合指标。

 

传统指标

传统疾病负担的衡量指标包括:用于描述和反映健康状况与水平的常规指标,如死亡人数、伤残人数和患病人数等绝对数指标;以及用来比较不同特征人群疾病分布差异的指标,如发病率、伤残率、患病率、死亡率、门诊和住院率等相对数指标。

 

上述传统疾病负担的衡量指标基本上只考虑了人口的生存数量,而忽略了生存质量,不够全面;但优势在于资料相对计算方便,结果直观,可用于各种疾病的一般性描述。

 

综合指标

疾病负担不等同于死亡人数,综合指标弥补了传统指标的单一性,且可以让各种不同疾病造成的负担之间相互比较。

 

潜在寿命损失年(YPLL):通过疾病造成的寿命损失来估计疾病负担的大小。但忽略了疾病造成的失能对生存质量的影响。

 

伤残调整寿命年(DALYs):将死亡和失能相结合,用一个指标来描述疾病的这两方面的负担。它包括因早死造成健康生命年的损失(YLL)和因伤残造成健康生命年的损失(YLD),即DALY=YLL+YLD。目前,DALY是国内外一致公认的最具代表性、运用最多的疾病负担评价指标。

 

健康期望寿命(HALE):指具有良好健康状态的生命年以及个体在比较舒适的状态下生活的平均预期时间,综合考虑生命的质量和数量两方面。

 

 

随着疾病负担研究的深入,其测量范围从流行病学负担扩大到经济负担。

 

疾病经济负担是由于发病、伤残(失能)和过早死亡给患者本人、家庭以及社会带来的经济损失,和由于预防治疗疾病所消耗的经济资源。

详细见:疾病的“经济负担”怎么计算?

 

参考资料:

陈文. 卫生经济学 [M]. 人民卫生出版社. 2017.

李茜瑶,周莹,黄辉等.疾病负担研究进展[J].中国公共卫生,2018,34(05):777-780.

什么是“年龄标化”?

在流行病学研究中,年龄是多种疾病的危险因素。以发病率为例,该指标反映了一定时期内,特定人群中癌症新发病例的情况。由于年龄是癌症发生的一个重要影响因素,年龄越大,发病率就越高。

 

如果两个国家的人群年龄结构相差很大,例如A市老年人口比例更大,B市年轻人口占比更高,直接比较两地癌症发病率的高低,我们不能确定发病率较高的市,是因为年龄构成不同还是因为其他影响因素(如饮食习惯、环境等)所导致。因此,需要用“年龄标化”的统计学方法,进一步处理数据,排除年龄影响因素的干扰,再来比较两地的发病率数据。

 

以发病率为例,即把原始数据套到一个“标准年龄结构人群里”,计算出”年龄标化发病率“,这样人群结构不同的A市和B市,就能在同一个指标尺度下进行“发病率”比较。年龄标化通常有“中标率”,即我国各地基于某一年份的中国人口年龄结构构成作为标准计算,国内不同地区的疾病数据比较采用的是“中标率”;另一种是“世标率”,即用世界标准人口构成机型标化计算,适用于国与国之间的指标比较。

 

同样地,以死亡率为例,应特别注意各之间地人口构成的差异。用标准化死亡率进行比较才能得出正确结论。如甲、乙两地在未标化前的肺癌死亡率相同,但实际上乙地人群的肺癌死亡率要明显地高于甲地,其原因在于甲地男性老年人口居多,而肺癌的死亡率又与年龄和性别有关,所以用未标化率进行比较时,就会得出甲乙两地肺癌死亡率相同的错误结论。

 

参考资料:

 

张科宏教授:年龄标化的患病率 – 丁香公开课 (dxy.cn)

科学网—癌症(粗)发病率与标化发病率的区别 – 杨雷的博文 (sciencenet.cn)

WHO年龄标化死亡率定义及计算方法

沈洪兵,齐秀英. 流行病学 [M]. 人民卫生出版社. 2015.

疾病的“经济负担”怎么计算?

疾病经济负担是由于发病、伤残(失能)和过早死亡给患者本人、家庭以及社会带来的经济损失,和由于预防治疗疾病的费用。通过计算疾病的经济负担,可以从经济层面上研究或比较不同疾病对人群健康的影响。

总疾病经济负担包括直接疾病经济负担、间接疾病经济负担和无形疾病经济负担。

直接经济负担:指直接用于预防和治疗疾病的总费用,包括直接医疗经济负担和直接非医疗经济负担两部分。直接医疗经济负担是指在医药保健部门购买卫生服务的花费,主要包括门诊费(如挂号费、检查费、处置费、诊断费、急救费等)、住院费(如手术费、治疗费等)和药费等。直接非医疗经济负担包括和疾病有关的营养费、交通费、住宿费、膳食费、陪护费和财产损失等。

间接经济负担:指由于发病、伤残(失能)和过早死亡给患者本人和社会带来的有效劳动力损失而导致的经济损失。具体包括:劳动工作时间损失、个人工作能力和效率降低造成的损失、陪护病人时损失的劳动工作时间、精神损失等。

无形经济负担:指患者及亲友因疾病在心理、精神和生活上遭受的痛苦、悲哀、不便等生活质量下降而产生的无形损失。

 

参考资料:

陈文. 卫生经济学 [M]. 人民卫生出版社. 2017.

李茜瑶,周莹,黄辉等.疾病负担研究进展[J].中国公共卫生,2018,34(05):777-780.