{"id":15681,"date":"2025-09-05T09:41:51","date_gmt":"2025-09-05T01:41:51","guid":{"rendered":"https:\/\/vaxlab.dukekunshan.edu.cn\/?post_type=publications&#038;p=15681"},"modified":"2025-09-05T10:04:22","modified_gmt":"2025-09-05T02:04:22","slug":"different-patterns-of-antimicrobial-non-susceptibility-of-the-nasopharyngeal-carriage-of-streptococcus-pneumoniae-in-areas-with-high-and-low-levels-of-pcv13-coverage","status":"publish","type":"publications","link":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/publications\/different-patterns-of-antimicrobial-non-susceptibility-of-the-nasopharyngeal-carriage-of-streptococcus-pneumoniae-in-areas-with-high-and-low-levels-of-pcv13-coverage\/","title":{"rendered":"Different patterns of antimicrobial non-susceptibility of the nasopharyngeal carriage of Streptococcus pneumoniae in areas with high and low levels of PCV13 coverage"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">This study from the Beijing Center for Disease Prevention and Control and the Beijing Research Center for Respiratory Infectious Diseases was published in Vaccine. In 2022, 2,333 healthy children under five from four sites in Hainan Province yielded 737 pneumococcal isolates. Grouped by individual PCV13 vaccination status and regional coverage, analyses showed significantly lower carriage of vaccine-type serotypes among vaccinated children (e.g., 6B: 7.0% vs 2.7%, P&lt;0.01; 6A: 4.2% vs 1.2%, P&lt;0.05; 23F: 2.2% vs 0.3%, P&lt;0.05). Overall Spn non-susceptibility was high to erythromycin (92.3%), azithromycin (87.5%), clindamycin (81.2%), tetracycline (91.2%), penicillin (38.9%), and cefuroxime (64.7%), with 82.9% of isolates being multidrug-resistant (notably 92.4% among vaccine-type strains). Isolates from high-coverage areas exhibited lower resistance and MDR than those from low-coverage areas, indicating that expanding PCV13 coverage could reduce vaccine-type carriage and the community resistance burden. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study from the Beijing Center for Disease Prevention and Control and the Beijing Research Center for Respiratory Infectious Diseases was published in Vaccine. In 2022, 2,333 healthy children under five from four sites in Hainan Province yielded 737 pneumococcal isolates. Grouped by individual PCV13 vaccination status and regional coverage, analyses showed significantly lower carriage of vaccine-type serotypes among vaccinated children (e.g., 6B: 7.0% vs 2.7%, P&lt;0.01; 6A: 4.2% vs 1.2%, P&lt;0.05; 23F: 2.2% vs 0.3%, P&lt;0.05). Overall Spn non-susceptibility was high to erythromycin (92.3%), azithromycin (87.5%), clindamycin (81.2%), tetracycline (91.2%), penicillin (38.9%), and cefuroxime (64.7%), with 82.9% of isolates being multidrug-resistant (notably 92.4% among vaccine-type strains). Isolates from high-coverage areas exhibited lower resistance and MDR than those from low-coverage areas, indicating that expanding PCV13 coverage could reduce vaccine-type carriage and the community resistance burden.<\/p>\n","protected":false},"featured_media":15676,"parent":0,"template":"","meta":{"type_label":"none_selected"},"class_list":["post-15681","publications","type-publications","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/publications\/15681","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/publications"}],"about":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/types\/publications"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/media\/15676"}],"wp:attachment":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/media?parent=15681"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}