{"id":16209,"date":"2026-01-24T09:00:00","date_gmt":"2026-01-24T01:00:00","guid":{"rendered":"https:\/\/vaxlab.dukekunshan.edu.cn\/?post_type=project-news&#038;p=16209"},"modified":"2026-03-02T10:54:19","modified_gmt":"2026-03-02T02:54:19","slug":"country-case-brazils-experience-with-school-based-hpv-vaccination","status":"publish","type":"project-news","link":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/project-news\/country-case-brazils-experience-with-school-based-hpv-vaccination\/","title":{"rendered":"Country Case: Brazil\u2019s Experience with School-Based HPV Vaccination"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Case Summary:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brazil introduced the quadrivalent human papillomavirus vaccine (4vHPV) into its National Immunization Program (PNI) in 2014, adopting a dual delivery strategy through both schools and health facilities. The program initially targeted girls aged 11-13 years, later expanding to 9\u201314 years, and became gender-neutral in 2017, while also including immunocompromised individuals. Currently, girls and boys aged 9-14 years and immunocompromised individuals aged 9-45 years (three-dose schedule) are eligible for free 4vHPV vaccination.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">In the first year of introduction, Brazil achieved a 94.4% national first-dose (D1) coverage, with 87% of municipalities reaching the recommended 80% target. School-based delivery played a central role, marking Brazil\u2019s first large-scale attempt to integrate routine immunization into schools. However, vaccine uptake declined sharply after 2016. Although first-dose coverage was high, national second-dose coverage fell to 40.8%, with only 32% of municipalities meeting coverage targets. A cluster of neurologic events temporally associated with HPV vaccination in 2014, later classified as immunization stress-related responses (ISRR), received widespread attention on social media and undermined public confidence. In the affected state, second-dose coverage declined to 44.6%, despite full recovery of all affected girls. In 2015, Brazil shifted HPV vaccination service from school-based approach to the primary healthcare provision, further reducing its accessibility and convenience. Combined with regional infrastructure disparities and the COVID-19 pandemic, national coverage dropped below 60% by 2020.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To reverse these trends, Brazil implemented multiple corrective measures. From 2017, eligibility was expanded to boys and immunocompromised individuals, and from 2024, a single-dose schedule was adopted for those aged 9-14 years. A nationwide catch-up campaign was launched to reach adolescents under 19 years who missed vaccination during the pandemic, with eligibility extended to December 2025. Authorities also renewed efforts to restore school-based vaccination, strengthened communication campaigns, and addressed vaccine-related misinformation online.These measures contributed to a recovery in coverage. By 2024, HPV vaccination coverage reached 82.8% among girls aged 9-14 years and 67.2% among boys in the same age group.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brazil\u2019s experience highlights challenge&nbsp;common to many middle-income countries: early success with school-based vaccination, followed by declines driven by misinformation, system-level changes, and external shocks. Evidence from Brazil suggests that restoring school-based delivery, simplifying schedules, maintaining gender-neutral programs, initiating vaccination at age 9, and investing in vaccine confidence are critical to achieving sustainable HPV vaccination coverage and preventing long-term setbacks in cervical cancer prevention.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em><strong><em>Recommended Studies:<\/em><\/strong><\/em><\/strong><strong><em><strong><em><\/em><\/strong><\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. Piorelli, R. O., Sato, H. K., Ara\u00fajo, N. V. D. L., Braga, P. E., Miyaji, K. T., &amp; Sartori, A. M. C. (2025). School-based HPV vaccination program implementation in municipalities of the S\u00e3o Paulo State, Brazil, from 2015 to 2018.&nbsp;<em>Cadernos de saude publica<\/em>,&nbsp;<em>41<\/em>(2), e00127423. <a href=\"https:\/\/doi.org\/10.1590\/0102-311XEN127423\" rel=\"nofollow noopener\" target=\"_blank\"><u>https:\/\/doi.org\/10.1590\/0102-311XEN127423<\/u><\/a>&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Braga A, Martins CAdO, Paiva G, Barboza \u00c9dA, Chagas M, Callado GY, Araujo J\u00fanior E, de Rezende-Filho J, Guimar\u00e3es ICCdV, Granese R, et al. Global Perspectives on HPV Vaccination: Achievements, Challenges, and Lessons from the Brazilian Experience. Vaccines. 2025; 13(11):1106. <a href=\"https:\/\/doi.org\/10.3390\/vaccines13111106\" rel=\"nofollow noopener\" target=\"_blank\"><u>https:\/\/doi.org\/10.3390\/vaccines13111106<\/u><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. Rosso, O. (2025, August 23). Brazil expands HPV vaccination campaign and surpasses the global average.&nbsp;<em>Brasil 247<\/em>.&nbsp;<a href=\"#google_vignette\"><u>https:\/\/en.brasil247.com\/saude\/brasil-amplia-vacinacao-contra-hpv-e-supera-a-media-global#google_vignette<\/u><\/a>&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Content Editor: Xinyue Zhou<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Page Editor: Ruitong Li<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Case Summary: Brazil introduced the quadrivalent human papillomavirus vaccine (4vHPV) into its National Immunization Program (PNI) in 2014, adopting a dual delivery strategy through both schools and health facilities. The program initially targeted girls aged 11-13 years, later expanding to 9\u201314 years, and became gender-neutral in 2017, while also including immunocompromised individuals. Currently, girls and [&hellip;]<\/p>\n","protected":false},"featured_media":16197,"menu_order":0,"template":"","meta":{"type_label":"none_selected"},"news-category":[73],"class_list":["post-16209","project-news","type-project-news","status-publish","has-post-thumbnail","hentry","news-category-research-en"],"_links":{"self":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/project-news\/16209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/project-news"}],"about":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/types\/project-news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/media\/16197"}],"wp:attachment":[{"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/media?parent=16209"}],"wp:term":[{"taxonomy":"news-category","embeddable":true,"href":"https:\/\/vaxlab.dukekunshan.edu.cn\/en\/wp-json\/wp\/v2\/news-category?post=16209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}